How do I get a job in one of these stores?

-I work nights in a assisted living facility and am so ready for a change plus its really hard on my back lifting people and such. I really want to get a job in safeway or toys r us or or rgis inventory or a store like that but I never did it before and I keep applying online and never hear anything back. How do I get a job like this? I keep applying every few months and no one ever contacts me back.